Searching for Organic Synthesis On Solid Support information? Find all needed info by using official links provided below.
https://en.wikipedia.org/wiki/Solid-phase_synthesis
In chemistry, solid-phase synthesis is a method in which molecules are covalently bound on a solid support material and synthesised step-by-step in a single reaction vessel utilising selective protecting group chemistry. Benefits compared with normal synthesis in a liquid state include: . High efficiency and throughput; Increased simplicity and speed; The reaction can be driven to completion ...
https://www.erowid.org/archive/rhodium/pdf/solid-supported.reagents.pdf
Abstract: The current interest in solid-phase organic synthesis has led to a renewed interest in a complementary technique in which solid supported reagents are used in solution phase chemistry. This technique obviates the need for attachment of the substrate to a solid-support, and enables
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118141649
Part Two, Applications, presents examples of the solid-phase synthesis of various classes of organic molecules. Chapters explore general asymmetric synthesis on a support, strategies for heterocyclic synthesis, and synthesis of radioactive organic molecules, dyes, dendrimers, and oligosaccharides.
https://pubs.acs.org/doi/abs/10.1021/jo015521z
The synthesis of a potential carbohydrate vaccine for the parasitic disease leishmaniasis is described. New solution- and solid-phase synthetic strategies were explored for the assembly of a unique tetrasaccharide antigen found on the Leishmania lipophosphoglycan. An initial solution-phase synthesis relied on thioglycosides as building blocks and the establishment of the central disaccharide ...Cited by: 90
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201001507
Synthesis of Aryl Fluorides on a Solid Support and in Solution by Utilizing a Fluorinated Solvent ... , Development of new methods in modern selective organic synthesis: preparation of functionalized molecules with atomic precision, Russian Chemical Reviews, 10.1070/RC2014v83n10ABEH004471 , …Cited by: 86
https://www.quora.com/What-are-the-disadvantages-of-solid-support-in-organic-synthesis
Aug 27, 2016 · Assuming the reaction can even be done using solid support, I would say the major disadvantage is scalability. Solid support resins have a high molecular weight, so a significant amount is needed even on 100 mg scale. They are also expensive. You ...
https://pubs.acs.org/doi/10.1021/jo9711807
A Novel Linking-Protecting Group Strategy for Solid-Phase Organic Chemistry with Configurationally Stable α-[N-(Phenylfluorenyl)]amino Carbonyl Compounds: Synthesis of Enantiopure Norephedrines on Solid Support. The Journal of Organic Chemistry 1999, 64 (7) , 2486-2493. DOI: 10.1021/jo982413c.Cited by: 115
http://www-oc.chemie.uni-regensburg.de/OCP/ch/chv/oc22/script/CombiChem-Handout-part1.pdf
Combinatorial Chemistry and Synthesis on Solid Support Burkhard König University of Regensburg Outline I. Solid phase synthesis 1. Polymers, resins, supports 2. Linkers 3. Analytical techniques Solid phase synthesis protocols and automatization 4. Peptide Synthesis a) Protecting groups (- CO 2H, -NH 2, side chain= Special topic: Photoremovable ...
http://chemlabs.princeton.edu/macmillan/wp-content/uploads/sites/6/CHL-soldsupp.pdf
Solid-Supported Reagents for Organic Synthesis á A recent review on functionalized polymers with an emphasis on chiral catalysts: Synthesis 1997, 1217-1239. á Main text references: Solid Supports and Catalysts in Organic Synthesis; Smith, K., Ed.; Ellis Horwood and PTR Prentice Hall: New York, 1992.
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