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https://www.drugs.com/drug-class/inotropic-agents.html
Inotropic agents are a group of medicines that affect the contraction of the heart muscle. Technically, inotropes can be divided into positive inotropes, which stimulate and increase the force of contraction of the heart muscle, and negative inotropes, which weaken the force of muscular contractions, decreasing how hard the heart has to work.
https://www.pharmaceutical-journal.com/learning/learning-article/use-of-inotropes-in-critical-care/11049283.fullarticle
Isoprenaline has a similar profile to dobutamine but tends to cause more tachycardia. It is sometimes used for bradycardic patients requiring inotropic support. Noradrenaline. Because noradrenaline acts primarily via a 1 receptors, it is usually used as a vasopressor (increasing SVR to maintain MAP) rather than an inotrope. It is often used with other inotropes, such as dobutamine, to maintain adequate …
https://www.texasheart.org/heart-health/heart-information-center/topics/inotropic-agents/
Inotropic agents, or inotropes, are medicines that change the force of your heart's contractions. Positive inotropes strengthen the force of the heartbeat. Negative inotropes weaken the force of the heartbeat. Both kinds are used in the treatment of many different cardiovascular conditions.
https://www.thecardiologyadvisor.com/home/decision-support-in-medicine/cardiology/interventional-pharmacology-inotropes-and-vasopressors/
Inotropes and/or vasopressors are essential in the management of cardiogenic shock complicating myocardial infarction/ischemia and in the treatment of hemodynamic instability occurring during coronary interventions.
https://link.springer.com/article/10.2165%2F00003495-199345050-00003
Oct 22, 2012 · Intensive care patients often require inotropic support to stabilise circulation and to optimise oxygen supply. In this context, the catecholamines norepinephrine (noradrenaline), epinephrine (adrenaline), dopamine and dobutamine are still the mainstay of therapy.Cited by: 31
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691094/
Dec 04, 2015 · Inotropes at home can be managed with the help of a home infusion program and a visiting nurse. Chronic heart failure patients awaiting heart transplants are candidates for intravenous inotropic support until the donor heart becomes available . This helps to maintain hemodynamic stability and keep the fluid status and pulmonary pressures optimized prior to the surgery.Cited by: 30
https://academic.oup.com/bja/article/90/4/525/274464/
Apr 01, 2003 · Editor—We read with interest the article on the incidence, and risk calculation for utilisation, of inotropic support in patients undergoing cardiac surgery.1 The findings of the independent predictors of ventricular dysfunction (presence of chronic obstructive pulmonary disease, age >65 yr, aortic cross clamp time >90 min), would be of no surprise to any cardiac anaesthetist.Author: C. Weidmann, M. Herbertson, A. Jünger
https://www.uptodate.com/contents/inotropic-agents-in-heart-failure-with-reduced-ejection-fraction
May 25, 2018 · The efficacy of acute intravenous inotropic support is well established in patients with severe myocardial systolic dysfunction. However, the efficacy of chronic administration of oral inotropic agents other than digoxin in ambulatory patients with HF remains unproven.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413841/
Inotropes and vasopressors are biologically and clinically important compounds that originate from different pharmacological groups and act at some of the most fundamental receptor and signal transduction systems in the body.Cited by: 115
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