Trophic Support Neurons

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Interleukin-10 provides direct trophic support to neurons

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737090/
    We found that IL-10 exerts a direct trophic influence on spinal cord neurons, and that activation of the neuronal IL-10 receptor provides trophic support and survival cues to overcome the neurotoxic effects of glutamate in vitro.Cited by: 120

Astrocyte–neuron interactions in neurological disorders

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750745/
    May 14, 2009 · Astrocytes have long been considered as just providing trophic support for neurons in the central nervous system, but recently several studies have highlighted their importance in many functions such as neurotransmission, metabolite and electrolyte homeostasis, cell signaling, inflammation, and synapse modulation.Cited by: 119

Trophic Support of Cultured Spiral Ganglion Neurons by ...

    https://www.jneurosci.org/content/17/6/1959
    Mar 15, 1997 · Trophic support by neuronal afferents can involve neurotrophic factors, cAMP, and membrane electrical activity. SGNs die after deafferentation in vivo and after isolation in culture.Cited by: 265

Developing require trophic support Evidence

    https://www.pnas.org/content/pnas/81/19/6245.full.pdf
    the trophic support ofDRG neurons or, alternatively, that the loss ofa postsynaptically derivedtrophic substancefrom the central terminal zones can be sufficiently replaced by trophic agents from the peripheral target cells to keep theCited by: 164

Pleiotrophin over-expression provides trophic support to ...

    https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-6-40
    Jun 07, 2011 · Pleiotrophin is known to promote the survival and differentiation of dopaminergic neurons in vitro and is up-regulated in the substantia nigra of Parkinson's disease patients. To establish whether pleiotrophin has a trophic effect on nigrostriatal dopaminergic neurons in vivo, we injected a recombinant adenovirus expressing pleiotrophin in the substantia nigra of 6-hydroxydopamine …Cited by: 22



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