Searching for Nucleoside Synthesis On Polymer Support information? Find all needed info by using official links provided below.
https://en.wikipedia.org/wiki/Synthesis_of_nucleosides
Synthesis of nucleosides involves the coupling of a nucleophilic, heterocyclic base with an electrophilic sugar. The silyl-Hilbert-Johnson (or Vorbrüggen) reaction, which employs silylated heterocyclic bases and electrophilic sugar derivatives in the presence of a Lewis acid, is the most common method for forming nucleosides in this manner.
https://www.sciencedirect.com/science/article/pii/S1381117707002871
Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support ... Abstract. Nucleoside analogue synthesis has received much attention because of the wide range of applications that these molecules offer. ... A new support for cell immobilization that involves the use of a macroporous polyethylene polymer grafted ...Cited by: 3
https://www.sigmaaldrich.com/chemistry/chemistry-products.html?TablePage=16255127
Oligonucleotide synthesis outside of biological systems is the chemical synthesis of nucleic acids of a predetermined sequence that may contain nucleosides beyond those that are naturally occurring. The ability to incorporate non-natural nucleosides into nucleic acids has led to many research uses such as: sequence detection; hydrolysis resistance
https://en.wikipedia.org/wiki/Oligonucleotide_synthesis
Oligonucleotide synthesis is the chemical synthesis of relatively short fragments of nucleic acids with defined chemical structure . The technique is extremely useful in current laboratory practice because it provides a rapid and inexpensive access to custom-made oligonucleotides of the desired sequence.
http://www.cs.unc.edu/~montek/dimpanbhatia/Nucleosides-Nucleotides-1995.pdf
nucleosides & nucleotides, 14(3-5), 829-832 (1995) a rapid method for the functionalisation of polymer supports for solid phase oligonucleotide synthesis k. c. gupta', pradeep kumar, dimpan bhatia …Cited by: 16
https://pubs.acs.org/doi/10.1021/jo702558n
Presence of the nucleosides on the support could be readily detected by MAS NMR. Exposure of the polymer-supported nucleosides, Pol-I and Pol-dI, to alcohol, phenol, thiol and amine nucleophiles caused cleavage from the support leading directly to the C-6 modified nucleoside analogues.Cited by: 21
https://www.sciencedirect.com/topics/chemistry/c-nucleoside
C-Nucleosides 552 and 558, the analogs of oxoformycin B and formycin B, were prepared from the isothiazol-3-yl C-nucleoside 550 as explained in Scheme 147 (93JOC5181; 94MI10).This scheme comprised two key steps: (i) the selective amidation of 550 at the more reactive C5 ester group to afford 553 as a result of proximity to the ring nitrogen, and (ii) transposition of the C5 amide in 553 to C4 ...
https://pubs.acs.org/doi/abs/10.1021/jo702558n
Exposure of the polymer-supported nucleosides, Pol-I and Pol-dI, to alcohol, phenol, thiol and amine nucleophiles caused cleavage from the support leading directly to the C-6 modified nucleoside analogues. To our knowledge, these are the first examples of the application of such technology for nucleoside modification.Cited by: 21
https://www.researchgate.net/publication/229112490_Nucleoside_synthesis_using_a_novel_macroporous_grafted_polyethylene_as_biocatalyst_support
Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support Article in Journal of Molecular Catalysis B Enzymatic 52(1):189-193 · June 2008 with 7 Reads
https://www.researchgate.net/publication/11005303_Photochemistry_on_Soluble_Polymer_Supports_Synthesis_of_Nucleosides
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