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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672709/
Many of the data on hydrocortisone are observational and relate to its use in inotrope resistant hypotension. In this situation, hydrocortisone seems to increase BP and allow weaning of other inotropic support.45 Noori et al33 have shown increases in BP, LVO, and SVR after 2 mg/kg of hydrocortisone in 14 babies with inotrope resistant hypotension.Cited by: 90
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857235/
May 08, 2016 · The choice of first line inotropic support has been dependent on clinicians. A homogeneous evidence-based treatment will benefit clinicians. This would allow health professionals to assess the problem further and consider next steps, whilst effectively treating hypotension in a safe way.Cited by: 3
https://www.researchgate.net/publication/221839124_Neonatal_Blood_Pressure_Support_The_Use_of_Inotropes_Lusitropes_and_Other_Vasopressor_Agents
Neonatal Blood Pressure Support: The Use of Inotropes, Lusitropes, and Other Vasopressor Agents Article · Literature Review in Clinics in perinatology 39(1):221-38 · March 2012 with 2,255 Reads
https://ep.bmj.com/content/96/6/216
Dec 01, 2011 · Inotropes are medicines that increase the force of cardiac muscle contraction. Inotropes are used to improve cardiac output and so increase oxygen delivery to tissues. There are very few pure inotropes. Most have other effects, which can help or hinder therapy. Deciding which inotrope to use, and when, is complicated for several reasons. The evidence base for these medicines is patchy ...Cited by: 5
https://casereports.bmj.com/content/2013/bcr-2012-008440
Jun 01, 2013 · We describe a case of a healthy male full-term neonate, 21 days old, admitted to the emergency room, presenting a severe cardiovascular collapse with an initial sinus rhythm. The first diagnostic hypothesis was of septic shock, having antibiotics, fluid resuscitation, inotropic drugs and ventilatory support started immediately. After achieving haemodynamic stability, a new cardiovascular ...Author: Eulália Viveiros, Ana Cristina Aveiro, Edite Costa, José Luis Nunes
https://journals.lww.com/pccmjournal/Abstract/2016/10000/Inotropic_Therapy_in_Newborns,_A_Population_Based.6.aspx
Inotropic treatment initiated in the first week of life (84.2%) was associated with birth asphyxia and pulmonary hypertension, whereas treatment initiated after the first week of life was associated with extremely preterm birth, neonatal surgery, neonatal sepsis, cardiac disease, and necrotizing enterocolitis.
http://www.motherbabyuniversity.com/outreach/outreach/PeaPods/PDFs/1873r%20SHOCK%20IN%20THE%20NEONATE.pdf
• Respiratory support should be given at whatever level the infant requires in order to maintain adequate oxygenation and ventilation. • Cardiovascular support may require the use of inotropic agents such as dopamine, dobutamine, or epinephrine. o Dopamine is usually the first choice. o Corticosteroids may be an option for infants who -
https://www.uptodate.com/contents/inotropic-agents-in-heart-failure-with-reduced-ejection-fraction
May 25, 2018 · Those with HF with preserved ejection fraction (HFpEF; also known as diastolic HF) do not need inotropic support, and the myocardial effects of these agents may be detrimental in such patients. The efficacy of acute intravenous inotropic support is well established in patients with severe myocardial systolic dysfunction.
https://www.researchgate.net/publication/277902958_Inotrope_and_Vasopressor_Support_in_Neonates
Inotrope and Vasopressor Support in Neonates. ... These data suggest that dobutamine is an effective but limited inotropic agent in the neonate. Dobutamine may be most beneficial when cardiogenic ...
https://www.spcnonline.com/download/guidelines/pcicsinfant/Care-of-the-Preterm-Neonate-Final-2016.pdf
Care of the Preterm Neonate with Congenital Heart Disease ... neonate for hemodynamic and inotropic support o Adverse effects: increased pulmonary arterial (PA) ... Inotropic medications to maintain adequate perfusion pressure of the shunt as indicated
https://fn.bmj.com/content/89/4/F348
The variations in cardiac troponin T concentration were significantly associated with oxygen requirement or the use of inotropic support in a regression model. Cardiac troponin T may be a useful marker of neonatal and cardiorespiratory morbidity. ... To establish a practical postnatal reference range for cardiac troponin T in neonates and to ...
https://academic.oup.com/icvts/article/7/1/116/648565
Patients in-hospital mortality was 20%, significantly higher than overall neonatal population admitted to our ICU (4.8%, P=0.02). Peritoneal dialysis in neonates allows optimal ultrafiltration rate and adequate small solute clearance, irrespective of hemodynamic status or vasopressor support.
https://reference.medscape.com/medline/abstract/27500723
CONCLUSIONS: This comprehensive epidemiologic study indicates that less than 0.3% of newborns receive inotropic support in the neonatal period. Dopamine was the most commonly used drug. Relating inotrope use to clinical condition, gestational age, and postnatal age may be useful for clinicians and helpful in delineating relevant patient ...
https://moh-it.pure.elsevier.com/en/publications/institutional-report-congenital-inotropic-support-and-peritoneal-
Institutional report - Congenital Inotropic support and peritoneal dialysis adequacy in neonates after cardiac surgery. Zaccaria Ricci, Stefano Morelli, Claudio Ronco, ... We describe the impact of cardiovascular pharmacologic support on peritoneal dialysis adequacy in 20 neonates who required postoperative renal replacement therapy following ...
https://www.slideshare.net/Dr_Padmesh/shock-inotropes-in-neonates-dr-padmesh
Oct 21, 2016 · Shock & Inotropes in Neonates - Dr Padmesh - Neonatology 1. Dr Padmesh Dept of Neonatology, Institute of Child Health, Chennai 2. • TOPICS FOR DISCUSSION: • 1. BRIEF HISTORY • 2. TERMINOLOGIES • 3. PATHOPHYSIOLOGY OF SHOCK IN NEWBORNS & UNIQUE FEATURES IN PRETERMS • 4. RECEPTOR PHYSIOLOGY • 5.
https://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/Neonatal_Pain_Assessment/
Inotropic support – a medication given as a continuous infusion, which alters the force or energy of systolic myocardial contraction to support the patient’s blood pressure. Sedated – the neonate is kept calm and put to sleep using a sedative drug, such as midazolam.
https://www.researchgate.net/publication/51783532_Inotropic_Support_in_the_NICU_Ever_More_Compounds_in_Search_of_Guidance
Neonatal asphyxia can be complicated by myocardial dysfunction with secondary alterations in pulmonary and regional hemodynamics. Levosimendan is a calcium-sensitizing inotrope that may support ...
https://litfl.com/inotropes-vasopressors-and-other-vasoactive-agents/
Apr 08, 2019 · inodilators are agents with inotropic effects that also cause vasodilation leading to decreased systemic and/or pulmonary vascular resistance (SVR, PVR) — e.g. milrinone, levosimendan; some agents don’t fit these categories easily! — e.g. dopamine; No inotropic agents have been shown to have superiority over any others in good quality trials.
http://www.adhb.govt.nz/newborn/Guidelines/Cardiac/PPHNManagement.htm
Infants with Persistent Pulmonary Hypertension of the Newborn (PPHN) are exceptionally unstable and difficult to manage. ... After initial resuscitation the management should always be discussed with the consultant on call. ... Use volume (initially normal saline) and inotropic support: dopamine and / or dobutamine, both starting at 5-10 mcg/kg ...
https://www.drugs.com/drug-class/inotropic-agents.html
Inotropic agents are a group of medicines that affect the contraction of the heart muscle. Technically, inotropes can be divided into positive inotropes, which stimulate and increase the force of contraction of the heart muscle, and negative inotropes, which weaken the force of muscular contractions, decreasing how hard the heart has to work.
https://en.wikipedia.org/wiki/Inotrope
An inotrope is an agent that alters the force or energy of muscular contractions.Negatively inotropic agents weaken the force of muscular contractions. Positively inotropic agents increase the strength of muscular contraction. The term inotropic state is most commonly used in reference to various drugs that affect the strength of contraction of heart muscle (myocardial contractility).
https://www.pcics.org/wp-content/uploads/2017/05/Care_of_the_Preterm_Neonate_-_Final_2016.pdf
Care of the Preterm Neonate with Congenital Heart Disease ... neonate for hemodynamic and inotropic support o Adverse effects: increased pulmonary arterial (PA) ... Inotropic medications to maintain adequate perfusion pressure of the shunt as indicated
http://www.motherbabyuniversity.com/outreach/outreach/PeaPods/PDFs/1873r%20SHOCK%20IN%20THE%20NEONATE.pdf
• Respiratory support should be given at whatever level the infant requires in order to maintain adequate oxygenation and ventilation. • Cardiovascular support may require the use of inotropic agents such as dopamine, dobutamine, or epinephrine. o Dopamine is usually the first choice. o Corticosteroids may be an option for infants who -
https://uichildrens.org/health-library/inotropic-agents
Inotropic support in patients with shock, hypotension, pulmonary hypertension with hypoxemia. Dose range. 2 to 20 µg/kg/min.; usually don’t need doses higher than 15 µg/kg/min. Usual starting dose range: 2 - 5 µg/kg/min. Adjust upward in increments of 2 - 3 µg/kg/min., based on desired increase in cardiac output / blood pressure.
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