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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495871/
It is important to recognize that since milrinone exerts its pharmacodynamic activity outside of the β-1 receptor, the drug maintains inotropic activity in the setting of recent or concurrent β-blockade. 59 No comparative trials have evaluated dobutamine and milrinone in patients with septic shock. Milrinone tends to be indicated less in patients with hypotension or renal impairment compared with dobutamine…Cited by: 4
https://journals.lww.com/ccmjournal/Abstract/2004/11001/Vasopressor_and_inotropic_support_in_septic_shock_.4.aspx
Objective: In 2003, critical care and infectious disease experts representing 11 international organizations developed management guidelines for vasopressor and inotropic support in septic shock that would be of practical use for the bedside clinician, under the auspices of the Surviving Sepsis Campaign, an international effort to increase awareness and to improve outcome in severe sepsis.
http://www.ucdenver.edu/academics/colleges/medicalschool/departments/medicine/intmed/imrp/CURRICULUM/Documents/A.pressors%283%29.pdf
This article focuses on vasopressor and inotropic support for patients with septic shock. Hemodynamic therapy of sepsis can be conceptualized in three broad cate- gories: (1) fluid resuscitation, (2) vasopressor therapy, and (3) inotropic therapy.
https://reference.medscape.com/medline/abstract/15542956
Norepinephrine or dopamine are the vasopressors of choice in the treatment of septic shock. Norepinephrine may be combined with dobutamine when cardiac output is being measured. Epinephrine, phenylephrine, and vasopressin are not recommended as first-line agents in the treatment of septic shock.
https://www.ptcommunity.com/journal/article/full/2015/7/438/vasopressor-and-inotropic-management-patients-septic-shock
It is important to recognize that since milrinone exerts its pharmacodynamic activity outside of the β-1 receptor, the drug maintains inotropic activity in the setting of recent or concurrent β-blockade. 59 No comparative trials have evaluated dobutamine and milrinone in patients with septic shock. Milrinone tends to be indicated less in patients with hypotension or renal impairment compared with dobutamine…
https://www.researchgate.net/publication/236036399_Inotropic_support_in_septic_shock
The objective of this study is to describe the hemodynamic effects, inotropic and vasoactive drug dependence, and to analyze the PO2/FiO2 ratio in 13 patients with septic shock of abdominal origin ...
http://www.surgicalcriticalcare.net/Guidelines/Vasopressors%20and%20Inotropes%20in%20Shock.pdf
recommendation for goal MAP in patients with septic shock is ≥ 65 mmHg (15). Literature is limited to support the safety of titrating MAP as high as 80 to 90 mmHg, with concern that a MAP this high causes excessive vasoconstriction that can adversely effect organ perfusion (17). An alternative endpoint is
https://www.medscape.com/viewarticle/451456
Oct 29, 2019 · Similarly, norepinephrine (noradrenaline) is a potent vasoconstrictor with additional inotropic properties. Because of inadequate data to support the use of one agent over another, the use of these drugs in treating septic shock is at the discretion of the treating physician,...
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