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https://www.ncbi.nlm.nih.gov/pubmed/9225114
The effects of the synthetic estrogen diethylstilbestrol (DES) (100 micrograms/kg), on lacrimal gland biochemical parameters in normal mature female rabbits was also studied. Ovariectomy decreased the total serum levels of testosterone (T) by 88.5% and androstenedione by 35.9%, without changing the levels of dehydroepiandrosterone (DHEA) of its sulfate.Cited by: 113
https://link.springer.com/chapter/10.1007/978-1-4615-5359-5_11
Thus, plasma estrogen concentrations do not appear to be a common variable in PLD. However, plasma free androgen levels are potentially decreased in all of these states. We have previously demonstrated that ovariectomy of female rabbits 2 and hypophysectomy of female rats 3 result in a decrease in biochemical correlates of lacrimal gland function.Cited by: 13
http://europepmc.org/abstract/MED/9225114
Mar 01, 1997 · The effects of the synthetic estrogen diethylstilbestrol (DES) (100 micrograms/kg), on lacrimal gland biochemical parameters in normal mature female rabbits was also studied. Ovariectomy decreased the total serum levels of testosterone (T) by 88.5% and androstenedione by 35.9%, without changing the levels of dehydroepiandrosterone (DHEA) of its sulfate.Cited by: 113
https://www.deepdyve.com/lp/springer-journals/androgen-support-of-lacrimal-gland-function-fANb3Ct7qn
Oct 28, 2007 · Androgen support of lacrimal gland function. 2007-10-28 00:00:00 The effects of dihydrotestosterone (DHT) (1 mg/kg) on biochemical parameters related to lacrimal secretion, basal tear flow rate, and pilocarpine-stimulated lacrimal gland fluid …
https://link.springer.com/chapter/10.1007/978-1-4615-0717-8_18
It has been reported that androgens play an important role in supporting the structure and function of the lacrimal gland. Androgen deficiency may be linked to the progression of lacrimal gland dysfunction and dry eye. 1 Sjögren’s syndrome is primarily a female disease, with 90% of Sjögren’s syndrome patients being women.Cited by: 15
https://www.sciencedirect.com/science/article/pii/S0014483502920543
Androgens and retinoids are known to be involved in control of lacrimal gland function. Because retinoids generally antagonize androgen function it was the purpose of this study to investigate interactions of retinoic acid and androgens in rabbit lacrimal acinar cells in culture by determining effects of retinoic acid on androgen receptor (AR) mRNA expression, AR protein levels and androgen ...Cited by: 20
http://www.gbv.de/dms/bowker/toc/9780306458125.pdf
Aberrant Lacrimal Gland Development in an Anophthalmic Mutant Strain of Rat p. 81 Hormonal Influences on Syrian Hamster Lacrimal Gland: Marked Repression of a Major 20 kDa Secretary Protein by Estrogens, Androgens, and Thyroid Hormones p. 85 Androgen Support of Lacrimal Gland Function in the Female Rabbit p. 89
https://www.sciencedirect.com/science/article/pii/S0014483508001589
Lacrimal gland insufficiency, one of the major causes of dry eye disease, is known to affect mainly postmenopausal women, where there is a significant decrease in the production of androgen and estrogen. These observations suggest that sex hormones might influence dry eye indirectly by regulating the expression of TL.Cited by: 7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132553/
Androgen binding sites have been found in lacrimal tissues of male and female rats, and androgen receptor mRNA has been found in the lacrimal glands of various species, including humans. 52 Furthermore, T-containing pellets enhanced lacrimal gland function, and systemic administration suppressed lacrimal gland inflammation in mouse models of SS ...Cited by: 11
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171493/
Na +/K +-ATPase, an enzyme located in the plasma membranes of all animals, has been detected in the LGs of rabbits [6,13,15-22] and rats [11,16,23-26], and it has been shown to play a significant role in LG function …Cited by: 4
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